We try to stay a metre apart, sleep separately and his clothes bedding are washed separately but back to normal after a week. The radiation levels are extremely low, the risk of cross contamination is tiny providing the guide lines are followed for the first week after treatment. We have not had scans yet so don't know the full results but our life has improved so much it's well worth a few days of inconvenience. So far he has had only 1 treatment, PSA is down to 3, his energy levels are very improved, he has gained weight and has very little pain. We sold our house and moved 8 hours south to be able to get it. We like in France and LU 177, Pluvecto has only just been approved here and is only available in 5 hospitals. The organ dose coefficients of this work showed some variation to the values reported from clinical studies and an earlier compartmental modelling study. PSA at 50 after all of that plus mega weight loss and total fatigue. The biokinetic modelling of 223Ra and its progeny may help to predict their distributions in patients after administration of Xofigo®.All ADT failed, 6 rounds Docetaxel followed by 8 rounds of Cabazitaxel, some mets diminished but others grew so considered to have failed. Our story is similar, same G score and mets in ribs, shoulders, spine and lymph nodes. How do I stay 3 feet away and drive him home from his appointment and provide assistance with standing, etc if his fatigue worsens? It seems an unreasonable risk to caregivers and others in the household. When I read about the radiation risk and think about him getting further fatigued it terrifies me. Our MO recommends Pluvicto as a next step, though it is not available in our area and we would need to travel a couple of hours if he is even accepted for treatment. Bone pain has returned (was alleviated during chemo treatment), he's lost over 60 lbs and is extremely fatigued. Recent PSMA PET scan showed most lesions decreased in size/intensity with two sites (rib and hip) showing further progression. Dropped Xtandi and completed 6 docetaxel sessions ending August 2022. PSMA PET scan in March 2022 revealed that cancer had progressed significantly throughout skeleton in spite of undetectable PSA levels. Didn't tolerate ADT well with extreme fatigue, weight loss, muscle loss, food tastes bad, chronic sinus inflammation. Started ADT with Firmagon April, 2021, and Xtandi May, 2021. Gleason Grade 4 + 4, oligometastatic with mets to ribs. Diagnosed April 2021, original PSA 19.59.
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